tag:blogger.com,1999:blog-11034229.post2824635671885027828..comments2023-07-14T02:53:40.719-07:00Comments on retired doc's thoughts: The new HFA inhalers may or may not help the environment and drug companies but are the users the forgotten men?james gaultehttp://www.blogger.com/profile/05537303135780186926noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-11034229.post-15189057312785531362012-04-12T14:36:06.769-07:002012-04-12T14:36:06.769-07:00For more information on bringing back CFC Inhalers...For more information on bringing back CFC Inhalers please check www.savecfcinhalers.orgAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-11034229.post-41035386071022355212009-03-23T10:33:00.000-07:002009-03-23T10:33:00.000-07:00Some folks are having some major problems with the...Some folks are having some major problems with the new HFA inhalers.<BR/><BR/>The most compelling story is at consumer affairs:<BR/><A HREF="http://www.consumeraffairs.com/news04/2009/02/asthma_hfa02.html" REL="nofollow">http://www.consumeraffairs.com/news04/2009/02/asthma_hfa02.html</A><BR/><BR/>Read the thousands of complaints at this petition:<BR/><A HREF="http://www.ipetitions.com/petition/saveCFCinhalers/signatures.html" REL="nofollow">http://www.ipetitions.com/petition/saveCFCinhalers/signatures.html</A><BR/><BR/>More complaints:<BR/><BR/><A HREF="https://www.savecfcinhalers.org/Guestbook.php" REL="nofollow">https://www.savecfcinhalers.org/Guestbook.php</A><BR/><BR/><A HREF="http://www.askapatient.com/viewrating.asp?drug=20503&name=PROVENTIL-HFA" REL="nofollow">http://www.askapatient.com/viewrating.asp?drug=20503&name=PROVENTIL-HFA</A><BR/><BR/><A HREF="http://www.opednews.com/populum/diarypage.php?did=11627" REL="nofollow">http://www.opednews.com/populum/diarypage.php?did=11627</A><BR/><BR/>If you are unhappy with the new HFA inhalers, kindly sign the petition to save CFC inhalers.<BR/><BR/><A HREF="http://www.savecfcinhalers.org" REL="nofollow">http://www.savecfcinhalers.org</A><BR/><BR/>Also worth mentioning from the FDA website is the following:<BR/><BR/>http://www.fda.gov/cder/foi/nda/2001/20-983_Ventolin-HFA_medr_P1.pdf<BR/><BR/>These quotes taken directly from the new drug application for Ventolin HFA.<BR/><BR/>"In the multiple dose adolescent and adult studies, albuterol HFA showed a numerically smaller improvement in FEV1 than was seen with albuterol CFC"<BR/><BR/>"There was other evidence that the HFA formulation delivers a lower/less effective dose on a per acutation basis than the CFC product. In the single dose, dose ranging study in adults, and in the single dose methacholine challenge study in adults one and two acutations of albuterol CFC were statistically indistinguishable in terms of effect, whereas significant differences were seen between one and two acutations of albuterol HFA. Finally, the combined adolescent/adult studies showed that the HFA formulation had a longer median time to onset of effect(4.2-9.6 minutes versus 3.6-4.2 minutes), had a shorter duration of effect(1.55-3.30 hours versus 2.29 - 3.69 hours), and was associated with more albuterol 'back up' use than the CFC formulation."<BR/><BR/>"We note that in the two 12 week clinical trials in adolescents and adults, Ventolin HFA Inhalation Aerosol consistently showed a smaller effect size than Ventolin CFC Inhalation Aerosol"<BR/><BR/>"Because it is expected that many physicians will prescribe Ventolin HFA Inhalation Aerosol for patients who have previously used the CFC formulation, it would be appropriate to include some description of the relative effectiveness of these two formulations in the product label."<BR/><BR/>"Unfavorable changes in physical examinations were observed in the ears, nose, and throat category as follows: 8% placebo HFA; 13% albuterol HFA; and 5% albuterol CFC."Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-11034229.post-17577261334898789802009-03-23T06:32:00.000-07:002009-03-23T06:32:00.000-07:00The customers/patients, like the doctors, have bee...The customers/patients, like the doctors, have been eliminated as sources of input and concern by the insurance carriers and the bureaucracies that governments use to maintain that monopoly. At teh edge, this cozy relationship could well lead to nationalized health, which in turn would be a wedge for nationalizing everything else.<BR/>Chuck Brooks<BR/>FutureWare SCGAnonymousnoreply@blogger.com