tag:blogger.com,1999:blog-11034229.post116730933887593546..comments2023-07-14T02:53:40.719-07:00Comments on retired doc's thoughts: Proton pump inhibitors, hip fracture and small relative risksjames gaultehttp://www.blogger.com/profile/05537303135780186926noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-11034229.post-24538710137443800322008-04-16T08:33:00.000-07:002008-04-16T08:33:00.000-07:00"We might not want to label an odds ratio from a c..."We might not want to label an odds ratio from a case-control study as impressive unless it is greater than 4 for minor adverse events and set this value progressively lower [for more serious events]."<BR/><BR/>Exactly. Set the bar lower for more serious events. I think 1.4 is enough for serious events such as a hip fracture. Also, if you look at the mechanism and the fact that osteoclasts have proton pumps in them the mechanism for this side effect is more understandable.<BR/><BR/>Check out this link:<BR/>http://www.prosanos.com/pvmaps004.phpAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-11034229.post-1167920926048534762007-01-04T06:28:00.000-08:002007-01-04T06:28:00.000-08:00Yes. Dr. Marcia Angell is - fortunately - a former...Yes. Dr. Marcia Angell is - fortunately - a former editor of the New England Journal of Medicine.John J. Coupalhttps://www.blogger.com/profile/14251189003749371248noreply@blogger.comtag:blogger.com,1999:blog-11034229.post-1167616693137334832006-12-31T17:58:00.000-08:002006-12-31T17:58:00.000-08:00"low stomach acid conditions can interfere with ab..."low stomach acid conditions can interfere with absorption of some forms of calcium"<BR/><BR/>Effects on strontium and magnesium absorption are also plausible, and the physiology of group 2 elements still holds many mysteries.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-11034229.post-1167616052709225442006-12-31T17:47:00.000-08:002006-12-31T17:47:00.000-08:00I should have identified Dr. Angell as a former ed...I should have identified Dr. Angell as a former editor of NEJM.james gaultehttps://www.blogger.com/profile/05537303135780186926noreply@blogger.com