tag:blogger.com,1999:blog-11034229.post6054913097508904180..comments2023-07-14T02:53:40.719-07:00Comments on retired doc's thoughts: Complex trials for complex condition can be ..well complexjames gaultehttp://www.blogger.com/profile/05537303135780186926noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-11034229.post-71493333652215534642008-02-21T04:19:00.000-08:002008-02-21T04:19:00.000-08:00Careful individualized and calibrated treatment of...Careful individualized and calibrated treatment of ARDS patients or anyone with a complex,rapidly changing clinical problem is what typically takes place in ICU and it is quite a lot to expect planners to be smart enough to devise protocols to replace that.james gaultehttps://www.blogger.com/profile/05537303135780186926noreply@blogger.comtag:blogger.com,1999:blog-11034229.post-51369559888739963732008-02-20T09:29:00.000-08:002008-02-20T09:29:00.000-08:00Maybe PEEP and insulin have similar theraeutic ind...Maybe PEEP and insulin have similar theraeutic indices. Studies of lower glucose control with insulin showed no great advantage in terms of CV mortality, at least some of the studies failed to show our dogma was correct.<BR/>So oxygen and pulmonary pressures can be bad, too. Maybe both types of patients need to have their treatment carefully calibrated to their individual response. If pO2 fails to rise with a bit more PEEP, cut it back until the pO2 is optimized.DocJimhttps://www.blogger.com/profile/13738477945703303268noreply@blogger.com