Featured Post

Is the new professionalism and ACP's new ethics really just about following guidelines?

The Charter ( Medical Professionalism in the New Millennium.A Physician's Charter) did not deal with just the important relationship of ...

Wednesday, February 21, 2018

diastolic heart failure-do we need a two (or more) hit theory?

Warning The following represents the musings of a non-cardiologist,clearly unqualified by training to speak with much credibility on this subject.

The earliest recognizable phase (s) of diastolic dysfunction seems to happen to everyone if they live long enough and late middle age may be long enough. This phase is labelled, in the jargon of echocardiography, as "impaired relaxation" and  according to the latest expert guidelines technically as " E/A ratio less than or equal to 0.8 and E  wave velocity less than or equal to 50 cm/sec."These values are obtained by measuring blood flow with Doppler technique across the mitral valve. Relaxation occurs simultaneously with elastic recoil (aka restoring forces) from which there is no current method to distinquish it.Authors addressing this topic seem fond of the spring analogy and it has been suggested that the world's largest protein molecule,titin,functions like a spring.

 To perhaps overly simplify a complex process,let us consider diastole or ventricular filling as a three phase event, pre-early, early and late.See end note 1 Pre-early is the phase after the aortic valve closes and before the mitral valve opens (the isovolumic relaxation phase),early is the phase when blood flow rapidly into the ventricle ( as  depicted by Doppler technique as the E wave) ,late is when blood is pushed from the atrium by contraction and represented a the A wave. In the young E is greater than A and remains so probably until about late middle age.when the E wave is no longer higher than A, the echocardiographer  now usually says "impaired relaxation"

The party line current theory describes the early phase of diastole as being driven by relaxation and diastolic suction. Extensive data show that several indices of  diastolic function change in the process of healthy aging. The ventricle takes longer to relax which is signaled   by a prolonged isovolumic relaxation time or IVRT. There is also slowing of the early flow across the mitral valve  depicted by a lower E wave velocity and a lower E/A ratio.

The early mitral velocity of blood flow decreases and the IVRT lengthens- changes believed to represent impaired relaxation and is reported as such on echo reports. (Even though it is generally agreed that there is no way to partition the relative effects of relaxation and diastolic suction as they occur at the same time.)  Simplistically diastolic suction function can be thought of elastic recoil,the release of the stored energy created by contraction. This is also referred to as restoring forces.  The late phase of diastole is influenced by the stiffness or compliance of the ventricle and the contractility of the atrium.

One of the missions of echocardiography is non-invasively estimate the "filling pressure" of the left side of the heart. Filling pressure is the  pressure at the end of diastole also referred to as preload.
Elevated filling pressure can be used to confirm or support the diagnosis of heart failure (HF) and is believed to correlate strongly with shortness of breath on exercise.

Since every one is thought to develop  a decrease early diastolic function but everyone does not develop diastolic heart failure ,could those patients with decreased ( or more decreased) ventricular compliance-which exerts its effect in late diastole- be the HFpEF candidates?

The story of the changes detected in the aging heart as depicted by the Group from Southwestern (1) goes like this:

Early on there is impaired relaxation.Left ventricular stiffening occurs during the transition period between youth and middle-age and "become manifest between the  ages of 50 to 64", This is followed by left ventricular volume shrinkage and remodeling ( wall thickening) after age of 65. So the sequence is impaired relaxation, stiffening and then remodeling.

There are data indicating that about 1/4 patients with stage 2 or 3 diastolic function    progress  to HF.(Impaired relaxation is stage 1, as ventricular stiffness builds up so does the pressure in the atrium and this is reflected with an increase in E ,and E/A increases , a pattern often referred to as pseudonormal (although the most recent ASC guidelines no longer use that term) , as things get worse the LA pressure increases more and values change appropriately earning the designation of restrictive pattern (again this is the older terminology banished by the 2016 revised guidelines)

So maybe a second hit is needed. One such hit could well be prolonged hypertension and the resultant concentric hypertrophy of the heart leading  to decreased ventricular compliance, or at least "ventricular chamber compliance".Left ventricular myocardial changes seen in obesity and diabetes could also represent a second hit and could contribute to both diastolic dysfunction and systolic dysfunction.

Myocyte apoptosis occurs with aging is accompanied by hypertrophy of the surviving myocytes and increase in fibrosis, all of which could conspire to stiffen the ventricle  as well as impairing relaxation.

The group from  Dallas (2) has presented data that a sedentary lifestyle can cause concentric cardiac hypertrophy and that prolonged aerobic exercise  ( at levels as least twice that of the standard exercise prescription which would be about 5 hours of moderate exercise per week) if started by early middle age may prevent the age related loss of ventricular compliance It should be noted that there are data and interpretation of data that contradict that hypothesis. See here  and here for commentary regarding the observations that more aerobic exercise is required to prevent diastolic heart failure that is sufficient to decrease the risk of coronary artery disease.

Diastolic heart failure is a well recognized companion of diabetes .Several possible second hit suspect mechanisms  have been described  in diabetes including deposition of glycation products and increase in myocardial cell tension.

Of course there is much more to it than that. Normal healthy aging per se has been associated with apoptotic loss of heart muscle cell,compensatory hypertrophy of remaining muscles cells and fibrosis leading to some stiffening of the ventricles with the only apparent "hit" being aging. But again that seems to happen to everyone and everyone does not develop diastolic heart failure.Maybe a second hit is needed and again according to the Dallas group a sedentary lifestyle may be one such second hit second hit.See here for commentary on effect of sedentary lifestyle on cardiac remodeling .

In broad, non specific terms the "second hit" is anything that increases cardiac stiffness.





1) Fujimoto,N. Effect of ageing on left ventricular compliance and distensibility in healthy sedentary humansThe Journal of Physiology2012 590 (pt 8)1871 (see end note 2)

2) Dr Benjamin D Levine N Fujimoto Paul Bhella and others have published extensively examining the effect of ageing,exercise and the lack of exercise on various aspects of cardiac function and age related impairment. They posit that long term endurance exercise begun at lest by middle age may prevent the loss of compliance that is common in sedentary human evens in the absence of the usual suspect heart problems (HBP,diabetes,obesity)


end note 1.I know there are "really 4 stages" I left out "diastasis"
end note 2. If anyone can explain to me the difference between compliance and distensiblity please comment.

Addendum 3/16/18 A few more additions to try and get this thing right.




Monday, February 05, 2018

Might meta analyses and meta data dreging gaslight everyone



Two dueling meta-analyses come to mind. There was a widely quoted meta analysis regarding Vitamin E which concluded it increased the risk of death. Soon after that article appeared in the Annals of Internal Medicine, letters to the editor claims that using a different statistical technique on the same data base, there was no increase in death risk.

Large data bases and multiple comparisons between outcomes and variables seem to always show that some factor becomes a risk factor for something often with relative risk values less than 2 and often less than 1.5.RR.Values in this range are unlikely per se to  unearth a causative factor.This activity is sometimes referred to as "data dredging"  or looking for a positive correlation to rush to print and press releases.

The prudent researcher usually emphasizes that these finding are "hypothesis generating" and not game changing breakthroughs although  the less prudent and the lay press and astro-turf propaganda outlets may suggest the latter. When apparently contradictory data then appear in the medical (and then the popular) press what is one to believe. This seems to be a cousin of "gas lighting" even though no one is plotting to make anyone doubt their ability to reason and analyze medical  data but  tons of data and sounding alarms on the findings of many  of them may have a similar effect of "not knowing what to believe".













Friday, January 19, 2018

Has the modern electronic medical record made many physicians accomplices to lying?

In the last few  years I have the opportunity to read my medical records  and those of  some extended family members. After reading these documents, I wondered- has the electronic medical record (EMR)  made doctors liars? When they sign off on a record that filled with erroneous statements and claims that something was done and it was not done and the physician knew it had not been done ,why would not lying be an accurate description ? I suggest it would be.

When I reflect back on the emphasis of the importance of accurate medical records that was  embedded into my nascent physician  mind as a medical student and house officer and  as I read the repetitive useless information, erroneous entries and pages of useless cut and past repetitions  and even fabrication of what transpired I cannot believe what the medical recored has become. So in some ways this is one of the saddest and most disillusioned  blog entries I have ever posted. In some cases the medical record has been useless and misleading and often inaccurate garbage and certainly potentially capable of harming the patient and likely a fertile field for plaintiff attorneys.

I read the medical records ( fairly easily obtained through the clinic's patient portal). I read that the patient had a physical exam ( describing normal finding for various parts of this phantom exam which she never had). No one listened to heart or lungs. Reading the medical history I find that she was said to have hyperthyroidism ( she had hypo) said to be on Armour thyroid  ( she is not) .Reading another orthopedics record ( again from the patient portal ) I learn that the summary sheet described the wrong leg bone as having the issue of concern i.e. tibia rather  than femur.

A few years ago I read on my own  colonoscopy report that my physical exam was normal. This was another phantom exam, this was being signed off by one of my former partners.

So would it be fair to describe this type things as publishing a false medical record or simply put lying. Court room scene. Doctor, your records on Mrs X indicate you performed a physical exam prior to her endoscopy?. Did you in fact do such an exam? Mrs X has testified that she did not have such an exam.


Do the physicians even know what is contained in the medical record that they sign? Is that any excuse if they sign the record?


Addendum:  2/8/18 Still more. Having  a pacemaker in place I take part in a "remote interrogation" of the PM every three months.This includes a summary done by a PM tech at the PM center at a local hospital. Each report ends with "the patient had no complaints". At no step in this process has anyone ever asked me how I am doing.

addendum 5/6/18 After remote interrogations every 3 months for two and one half years,at last the technician actually asked me how I was doing  and if I was having any problems.

Addendum 6/30/21 I write about further instances of phantom exams in as blog post about the Cures Act.

Wednesday, January 17, 2018

Mayo study: higher cardiorespiratory fitness associated with lower risk of atrial fibrillation

Data and analysis continues to address the issue of exercise level and risk of atrial fibrillation (AF)-sometimes referred to as the U-shaped curve controversy.

Hussain et al (1) published a follow-up study on 14,094 selected subjects who had been referred to Mayo Clinic for exercise stress testing. These were from a much larger group from whom those with a history of heart failure, atrial fibrillation or flutter or stroke were excluded.The average follow-up was 14 years and the outcomes of interest were incident atrial fibrillation ,stroke and death.
They divided the subjects into 4 groups based on functional cardiorespiratory capacity as estimated by their performance on the Bruce protocol stress test.

Those subjects in the highest exercise performance category showed no increase in the risk for AF.

The authors concluded:

"...better cardiorespiratory fitness is associated with lower risk of incident AF, stroke and mortality. Similarly risk of stroke and mortality in patients with AF is also inversely associated with cardiorespiratory fitness."

They also commented that the reduction in these risks with increasing exercise capacity  "may be a direct physiological effect of exercise and physical activity or a consequence of a lower burden of cardiovascular risk factors" I would add "or both".

This is  another coarse grain study which will not settle the U shaped curve argument.I think often these "controversies " just dwindle away rather than get settled. The etiology of AF and stroke with AF involves a complex array of numerous possible  and possibly interacting input variables and here we look at the effect of  only one such variable ( exercise capacity-as a surrogate for exercise level) on the outcome (s) but at least  long time endurance exercisers may find some solace here. Critics can justifiably point out that a number of potentially confounding variables were not available  for analysis including, smoking history,alcohol use,and actual exercise habits.

Again quoting  Simon (2) ".. a man hears what he wants to hear and disregards the rest"





1) Hussain,N Impact of cardiorespiratory fitness on frequency of atrial fibrillation , stroke,and all cause mortality. AJC Jan 1, 2018. vol 121 issue 1, p 41-49

2) Simon, P .Lyrics from the song ,The Boxer, 1969


H/T "notes from DR RW"

Monday, January 15, 2018

Not your father's internist any more

This a very lightly edited version of a commentary that I made 12 years ago. Nothing has happened in the last 12 years to change my views and from the point of view of a very over the hill internist, things are even worse and are not likely to get better.




"The current data are clear.There are fewer docs going into general internal medicine.Lower pay and  less prestige are two of the reasons offered and an increasing amount of onerous,often counter productive computer driven requirements may for some be the final straw.

A  "op-ed" like piece in the ACP Observer by the President D. Anderson Hedberg is entitled "Finding the Art within the science of internal medicine". My gut reaction to it is " wouldn't it be nice if it were [still] true.?"The internist he portrays does resemble the internist I thought I was training to be. But I doubt if it is possible to be that type physician today.(see end note )

Dr. Hedberg quotes a 1998 article by Dr. Robert L. Wortmann, chair of IM at the U. Of Oklahoma in Tulsa. Dr. Wortman said the four distinguishing characteristics of internists are: 1) the ability to be a diagnostician ( internists were once called that) who can practice the deductive scientific process that leads to therapy. 2) the ability to provide care of complex acute and chronic problems. 3) the ability to be a consultant for generalists, specialists and subspecialists and 4) curiosity. One comment he made re "curiosity" does resonate with my IM training. He said that to the internist it is important to consider the "links between disease and pathophysiology as well as between the therapy and its mechanism of action"

These comments definitely had more currency at a time when: 1) there was no competition in primary care save for GPs. and there was a clear distinction between GPs and internists. There were no family doctors-from whom the distinction between them and internists is harder now to draw- and no competition from nurse practioners. 2) there was the reasonable likelihood of being able to spend enough time with a patient to play out those characteristics and patients did not have to be seen every 10-15 minutes to either meet the clinic or HMO quota or generate enough income to keep the practice going. 3) there was no need to worry and try and determine if the recommended therapy was approvable by the HMO, Insurance company or pharmacy management company.4) there was no hospitalists to compete with you. You were the hospitalist. 5) there was time and opportunity to pursue efforts to satiate your curiosity.

Only about 25 % of internists consider themselves general internists and more and more subspecialists refer back to the general IM doc or the FP problems not clearly linked to their subspeciality.Hospitalists are growing in numbers and the arrow points in the direction of at least some general IM docs pulling back from their roles in the hospitals making them more like FPs than internists.

In short, in today's environment how realistic are the comments of the two physicians quoted above? I think not very. I am afraid their comments were more relevant in an earlier era.It is hard to say what are the distinguishing characteristics of internists in the current practice of medicine.
I believe it is a confluence of factors and forces that are leading to the demise of the general internist.

Another major determinative factor is the following:A few decades ago the internist (there was no "general" preceding the designation) was the recognized expert in diseases of the heart, lungs, and kidneys as well as the expert in endocrinology and hematology. Tremendous growth and development of the subspecialist domains of expertise has changed the landscape. Cardiologists are now called in to treat coronary syndromes, pulmonary docs for respiratory failure, etc etc. Oncologists take care of the cancers, kidney doctors the ESRD cases and it is the rheumatologists now giving the disease modifying treatments for rheumatoid arthritis .When emergent or semi-emergent medical issue arise after hours the patient is likely seen in the ER by an ER doc and if hospitalized, then seen by a hospitalist who more likely than not calls in specialists.In short, the areas in which the internist was the expert have largely disappeared and the experts are the IM subspecialists and it is the ER docs and hospitalists who sort out the problems of sick patients summoning subspecialists as needed.

To a large degree many internists are left with office treatment of the same conditions managed by FPs and nurse practitioners ( hypertension, type 2 diabetes,annual check ups, elevated cholesterol,URIs etc, annual "check ups" )



How many internists would want their myocardial infarction treated by an internist? I want a cath cardiologist.


end note: I do not deny there are exceptions. I have been a big fan of the blog ," db's medical rants" by Dr. Robert Centor,an academic internist who as best  I  can tell from his writings continues to function in the manner described by Dr. Worthmann.However he does not seem to  work primarily  in a private practice setting the landscape of which , in the last few decades ,has become a completely different game.

Addendum: 2/9/18 My own internist who is also my former partner finally decided to find a internist for his medical care.The one he chosen has an excellent CV board certified,good med school,good residency site etc. He said he liked him, he seemed nice  but it was "sorta funny" that he did no physical exam at all.

Saturday, January 13, 2018

LBBB associated non ischemic cardiomyopathy -more favorable remodeling if CRT started early

 An article by the electrophysiology group at the University of Pittsburg highlights the importance of early CRT in cases of left bundle branch induced non-ischemic cardiomyopathy with heart failure.

 First some background:

The effect of LBBB on ventricular function has been recognized at least since the 1980s and abnormal septal movement  described as  early as 1973 (4). See here for my review of the abnormal cardiac function observed in LBBB.

LBBB induced cardiomyopathy and its potential reversibility by CRT was described at least as early as 2005 in an article by Jean-Jaques Blanc(1). In 2008 Blanc co-authored a chapter on that topic in Barold and Ritter's book  "Devices for Cardiac Resynchronization" (pg 139-145)

In 2013, Vaillant et al (2) described 6 patients with so-called isolated LBBB who developed heart failure and in whom a marked improvement in cardiac function was documented following the institution of CRT.

Wang and Saba et al (3) from Pittsburg studied 123 patients with LBBB-associated idiopathic non-ischemic cardiomyopathy. About half were treated with CRT in less than 9 months after diagnosis and half received CRT after 9 months.

Improvement in left ventricular ejection fraction to greater than 35% was more likely in those who received earlier treatment. The author concluded in part " Delaying CRT may miss a critical period of halt and reverse progressive myocardial damage"

I suggest the importance of this paper is not that earlier is better than later (which seems expected) but rather that,to my knowledge, this is the first paper describing a  large number of patients with  LBBB induced cardiomyopathy   and their response to CRT. To my knowledge ,only a handful of patients had been described previously and this article should perhaps serve to make this entity better recognized.

The patients were treated with CRT which, so far, has been virtually synonymous with bi-ventricular pacing (Bi-V). Now , however, more patients are being paced with His Bundle pacing. There is some developing evidence that His Bundle pacing is  at least equivalent in terms of efficacy to Bi V pacing. His bundle pacing certainly seems more physiologic. His bundle pacing is capable of making the abnormal LBBB QRS complex normal or nearly so in the majority of  cases.Alberti et al  (5) from the University of Florence make the case for His Bundle pacing as an alternative to Bi-ventricular pacing in CRT and note sthe ongoing clinical trial (the HOPE_HF trial)  using His Bundle pacing in CRT eligible patients.Actually in 2015, Lustgarten et al(6) demonstrated an equivalent CRT response
of Bi-V pacing  in a cross over trial with His Bundle pacing in 29 patients.

All of Wang's patients were treated for 3 months with the  standard heart failure regimen but responded poorly and then with CRT. What about patients who develop "lone" LBBB and have a history of decreased exercise tolerance but ejection fractions still within the normal range? Should the patient be required to have overt HF and poor response to medication before  CRT is considered?

Again a personal note in this regard.  Two years ago  I developed LBBB and my exercise capacity decreased immediately . My echo showed a EF in the normal range ( lower limit) and mitral Doppler flow indicated impaired relaxation and stress echo showed abnormal septal movement. I had also developed an exercise induced high grade second degree heart block and on that basis was a candidate for a pacemaker. I was fortunate to have an EP cardiologist who was doing His Bundle pacing (few were at that time  at least in my area) and after a series of  uncommon post procedure complications (including pulmonary embolus,and pocket hematoma) were resolved I was able to enjoy a return to a level of exercise ability indistinguishable from my pre conduction problems status and I believe avoided the likelihood of a progressive LBBB induced cardiomyopathy.

Three cheers for His Bundle pacing.





1)Blanc J, Evaluation of left bundle branch block as a reversible cause of non-ischaemic dilated cardiomyopathy  with severe heart failure . A new concept of left ventricular dyssyncrhony-induced cardiomyopathy Europace. 2003  7 (6) 604-610

2)Vaillant et al. Resolution of left bundle branch block induced cardiomyopathy by cardiac resynchronization therapy.JACC 2013 vol 61 no 10  pg 1089


3)Wang,NC et al New onset left bundle branch block-associated idiopathic nonischemic cardiomyopathy and time from diagnosis to cardiac resynchronization therapy. The NEOLITH II study PACE 2018 Jan 4

4)Breithandt,G. Left bundle branch block,an old-new entity.J. Cardiovas Tranal Res2012 ,Apr 5 2 107. (authors reference the work of Curtius and of McDonald.


5)Alberti, L Hemodynamics of His bundle pacing. J of electrocardiology 50 (2017) 161-168


6)Lustgarten DL et al His-bundle pacing in cardiac resynchronization therapy patients.a crossover design comparison.Heart Rhythm 2015;12 1548-57

Wednesday, January 10, 2018

The ABIM Foundation, "a foundation dedicated to what?"

Following a revealing blog post regarding the ABIM  by DRWes, a  comment was made by Keith:

" This is what happens when a non profit organization loses site of it's true mission and becomes more focused on the dollars. Looks like they are generating so much loot from their plundering of physicians that they needed somewhere to hide it. Why not create a foundation (the ABIM Foundation) dedicated to what ????"

 So what is it dedicated to?

The key document which outlines the purported current missions of the  ABIMF is the 2002 publication of "Medical Professionalism in the New Millennium:A Physician Charter" .

According to the ABIMF's website: "The Fundamental principles of the charter are primacy of patient welfare,patient autonomy and social justice. "

The first two are long established principles of medical ethics about which there is little controversy  ,but the third is another matter

From a tactical point of view the use of term social justice" has a number of selling points.First, while everyone who would consider themselves progressive (or modern liberals) would support social justice, many of a conservative or libertarian mind set would not. The term social justice is loose and indeterminate and therein again lies is rhetorical value. To many social justice connotes helping the disadvantaged.and  conservative and libertarians are not going to be speaking out against helping the poor etc but differ from progressives in the permissible techniques to bring that about.But to the founders of the Charter helping the disadvantaged  may not be  the driving force.

 We are told that new new medical professionalism is about a "fair and equitable distribution of finite medical resources" and that physicians have an obligation to move toward that goal. At this point readers of the charter might well wonder how, as practicing physicians, how would they accomplish that move.  Well, we are told that physicians can practice cost effective medicine and that may well be best done by following guidelines.In that way they can be the stewards of the finite resources.So it seems that " fair and equitable" corresponds to "cost effective" which for an individual physician that translates to " follow the guidelines"

So  now the bait and switch, the bait is a obligation to promote social justice and the switch is to follow guidelines which is claimed to bring  about  fair and equitable distribution of resources.

Yet you have to ask is this striving for purported social justice the reason for the existence of the ABIMF or  is it to save money for third party payers?ABIM accumulated a significant amount of money by testing internists for board certification and found themselves holding many millions of dollars . This was profit in the sense of receipts greatly exceeding their costs but a non profit does not make a profit by definition even if their monetary intake greater exceeds their monetary output. ABIM itself is a non profit.




Monday, January 08, 2018

The long term trend of how and where decisions are made

I continue to be impressed by the depth of the insight found in Thomas Sowell's "Knowledge and Decisions".

Here is my attempt to discuss some part of it that.


One of the major constraints facing human is lack of knowledge for making the many decisions they have to make in the business of living and just getting by.But decisions have to made and analysis of how and where these decisions are made offer meaningful insight into a lot of which transpires.

We can speak of decision making units (DMU) ( my abbreviation) and attempt to examine the processes involved .Much can be learned about that by looking at the incentives and constraints under which the DMUs operate and the extent to which their (its?)decisions and actions are subject to feedback.The DMUs also may vary in the extent to which they engage in incremental trade offs as opposed to categorical solutions.Sowell correctly emphasis that for analytic purposes one should not look at an organization's purported "mission statement" but rather at their incentives and constraints

Sowell contends that over time in the United States there has been a shift in the locus of the decision making.There has been a shift from decisions traditionally made in the home to the school, from businesses to various governmental agencies and to the courts. Further, within government there has been a major shift from decisions made by the legislative branch,concerning which voters have at least the chance of influencing the decisions, to the executive branch with its too numerous to list agencies and departments which are much more immune to the power of the vote and more insulated from public feedback and often given much difference by the courts.

These administrative entities  have  " .... political initiatives and its own external constituencies developed as a results of initial mandate, constantly pushing for an expansion of its activities and benefits." ( from page 318 Sowell, "Knowledge and Decisions" Basic Books, 1980,)

Medical decision making has also migrated from the decisions made by the individual patient physician "dyad" to more central decision making directly and/or indirectly by insurance companies,large medical  practices, pharmacy management companies and HHS.


addendum: 1/20/18 The title was changed. The title was appropriate for a much earlier version of the post written in regard to a particular piece of legislation ,reference to which was deleted in the final version. My apologies for sloppy editing.







Sunday, January 07, 2018

"..how little they really know about what they imagine they can design" -Mega medical hubris

Frederick Hayek was talking about the "curious task of economics " That sentiment can as easily be applied to the central planners of medicine. Dr. Donald Berwick has written about the "need" medicine has for "[wise] leaders with plans".

Five years ago I blogged about the need for a lecture for medical students to underline the dangers of hubris.The type of hubris exhibited by the recently minted expert typically is a self limited affliction as growing experience overwhelms earlier exaggerated estimates of one's knowledge and medical expertise.

Nowhere is hubris more highlighted than it is in those intellectuals who profess to know what it best for others, everyone.This is not the  usually limited hubris of the novice but rather a permanent more exuberant hubris typical of the self appointed philosopher leader who profess to know what is best for everyone as is the case with the self appointed spokesmen for population medicine.

The notion of wise leaders with plans ( for others) finds historical precedence in Plato and his advocacy of philosopher kings.




Friday, January 05, 2018

Echocardiography in the elite athletes of the NBA

The stylized athlete's heart is described as having an increased left ventricular end diastolic volume,a thickened left ventricular wall and increased  left ventricular mass.

Electrocardiograph studies have been reported in soccer players and cyclists largely from Europe.It has been recognized for years that different patterns of cardiac remodeling result from various forms of athletic activities typically depicted as the dichotomy between patterns described in  endurance athletes and in  resistance trained athletes.

Recently (1) a large amount of data has been published on US professional basketball players.These were players on the active rosters of all the NBA teams from the 2013-2014 and 2014-2015 seasons. Testing was done at several locations and sent to the cardiology department at Columbia for analysis.

That publication should be of value to cardiologists faced with issues involving cardiac evaluation of basketball players as regards HCM and Marfan's Syndrome.  Sudden cardiac death is most common among basketball players and HCM is the leading cause.

1) Engel , DT Athletic cardiac remodeling in U.S. professional basketball players.JAMA Cardiology 2016:1(1), 80-87

Wednesday, January 03, 2018

How traditional medical ethics got highjacked and why?

For as long as the dominant medical ethical precept and prime directive was do what it right for the individual patient,third party payers were challenged to control medical costs to the degree they desired because they could not control the folks whose hands were on the cost levers. That just might be the answer to the why.

Traditional Medical ethics stood in the way of the third party payers efforts to control costs and in regard to the private health insurers  to maximize profits.

With the why out of the way, lets move on to the how.

First, we look at an early trial balloon of the plan to disabuse physicians of what to the third party payers was a very dangerous notion namely that the physicians had a fiduciary duty to their patients.

The following gives a flavor of several publications from major medical publications that launched the trial balloon and does not claim to be an exhaustive literature review of medical article promoting that theme.


In 1988 Dr. Robert A. Berenson and M. Hall, a law professor, writing in the Annals of Internal Medicine said that "the traditional ideal" [the traditional doctor patient relationship in which the doctor's duty was to the patient] was "not compatible with the role that existing insurance contracts and manged care arrangements define for physicians."

They were explicit when they said : (my bolding)

We propose that devotion to the best interests of each individual be replaced with an ethic of devotion to the best interests of the group for which the physician is personally responsible.

The authors were saying that insurance companies and managed care companies were defining the physician's role and that physicians needed to simply change their ethical precepts and get with the program.Some may recall that one of the characteristics of a profession (which medicine once was) was that it defined its ethics not an outside party. So the old ethics just does not work any longer.


Berenson and Hall proposed a complete revision or negation of the medical ethics that existed from hundreds of years.This fiduciary duty to the individual patient should be replaced by a nebulous co- duty to medical collective to which the individual patient belonged. As outrageous as that appeared to someone trained in the traditional medical ethics, an obligation to serve the greater needs of society and to balance that against the individual patient's welfare has subsequently appeared to be widely accepted ( at least by many medical society  leaders and spokesmen) by various medical organizations. See here the New Professionalism as promulgated by the American College of Physicians. But I get ahead of the narrative.

Dr. David Eddy authored a series of articles in JAMA ( Eddy DM. Rationing resources while improving quality.How to get more for less.JAMA.1994:272,817-824) promising to teach physicians how they could increase quality and save money at the same time.

The trick was the utilitarian imperative-do the greatest good for the greatest number. In his moral calculus it was not only appropriate but it was ethically demanded that, for example, one would not waste money by for example offering yearly mammograms to women between 40 and 50 if a greater bang for the buck could be achieved by offering smoking cessation session to pregnant women. Cost effectiveness analysis was to guide what was offered to the group It was the health of the collective that mattered and that was true even if the collective was a thrown together bunch of strangers whose employers happened to sign up to a given HMO. The traditional fiduciary duty of the doctor to the patient as well as the legal manifestations of that relationship and the aspect of human nature that says I want what is best for my health and my family's health not for some alleged aspect of a fictional collective would have to moved past.

Doctors were admonished by Eddy to not be "hoarding resources" for their patients.Note his approach went past cost effectiveness concerns and even past comparing the cost and benefits for alternative approaches to the same disease. He was suggesting making judgment about what disease money should be used for and what sub-group of members of the collective should benefit and which should not.

Another significant shot across the old medical ethics bow was offered by Dr. Donald Berwick and Dr. Troyen Brennan with their book, "New rules" published in 1996. The authors were as explicit as was Dr. Berenson when they wrote:


"Today, this isolated relationship[ he is speaking of the physician patient relationship] is no longer tenable or possible… Traditional medical ethics, based on the doctor-patient dyad must be reformulated to fit the new mold of the delivery of health care...Regulation must evolve. Regulating for improved medical care involves designing appropriate rules with authority...Health care is being rationalized through critical pathways and guidelines. The
primary function of regulation in health care, especially as it affects the quality of medical care, is to constrain decentralized individualized decision making.

Dr. Berwick later received a recess appointment to head CMS while his co-author later become CMO and VP for Aetna (2006-2008) and subsequently CMO and EVP of CVS Caremark.Dr. Berenson has held several positions in federal government icluding vice chair of the Medicare Payment and Advisory Committee (MED PAC).


Next we look at the charter for the New Medical Professionalism which was published in the Annals of Internal Medicine in 2002 as internists on both sides of the Atlantic offered a faux solution to the problems that medical practitioners faced in the new century .Dr. Brennon played a major role in that effort.

The authors listed various problems facing physicians and then gratuitously offered the mother of all non sequiturs namely that presumably these multiple problems (a barrage of new drugs and technology,changes in market forces,etc) could be solved by physicians working for social justice and an equitable distribution of society's medical resources as well as working to promote and respect patient autonomy and the principle of the patient's welfare.Social justice was bundled with the other two non controversial principles. Think about that "solution", to mitigate the myriad of problems the proposal was to maintain principles physician had upheld for a long time and add on an obligation to work for social welfare. As if physicians did not already have have enough to do. This was not an ethics handbook ( that would come later ), rather this was a "charter" , a set of commitments for medical professionalism which they defined as the basis for medicine's imaginary contract with society.

In 2007 the same or very similar theme was played again , this time by Dr. Brennan , who by this time had become VP of Aetna in an article entitled "Managing Medical Resources, A return to the Medical Commons" , coauthored by the then President of ACP Dr. Christine Cassells.(JAMA,June 13,2007,Vol 297,#20,pg 2518.



Here,the authors speak of an abstract, hypothetical " medical commons" and lament that the current emphasis by the physician for the welfare of the individual patient will spoil the commons much as the farmer who selfishly grazes his cattle on public land without regard for depleting the resource will destroy the resource.Physicians are implored to "reconstitute the medical commons" and think in terms of resource conservation and allocation so at the end the greatest medical good can be done for the greatest number of patients.They admit there is not currently such a commons. There never has been so I am unsure how a return is possible.

The medical commons figure of speech seems particularly lame.While a grassy knoll for the villager's sheep can be defined by a specific surveyor description, the "medical commons" is a extremely large amorphous array,the elements of which almost defy enumeration, and every changing, with some elements growing ,others contracting and innovations cropping up constantly.There is no easily defined entity called "medical resources";it is an amorphous abstraction.Further, to speak of allocation means some one or some elite group will be the "allocator in chief ". Decisions will not be made by thousands of individual physician-patient pairs.

Cassell and Brennan assert that a market based on a regulatory approach will allocate resources without the caring and wisdom that clinicians can bring to the endeavor. In their analysis the only choice is a medical commons with physicians and patients moving hand in hand willing to put aside the petty concerns of the individual when necessary for the greatest good of the group.

This is not the only publication wherein an officer of a large insurer found a friendly home either with a ACP officer as co-author or in a ACP journal to espouse a similar theme.

The journal of the American College of Physicians (ACP), the Annals of Internal Medicine, in 2006 featured a five page article in which the former CEO, and then current board member of Aetna, Dr. John W. Rowe, pontificated on the "moral basis for physicians..to participate in...[P4P]." I commented on that article at the time and noted that Aetna's reputation among practicing physicians was such that Dr. Rowe might not have been the most credible witness to present the case for P4P , a movement which the ACP has tended to favor. In a comment to my blog entry Dr. Roy Poses pointed out more details concerning Dr.Rowe's association with Aetna , namely that he owned 6 million shares and that he was actually chairman of the board of Aetna and that , of course, Rowe has a fiduciary duty to act in the interests of the company.


Then in 2012 came the new ethics manual of the American college of Physicians ( Published as a supplement to the Annals of Internal Medicine Jan. 2012,
American college of Physician ethics Manual, sixth edition;) Here is one quote:

Physicians have a responsibility to practice effective and efficient health care and to use health care resources responsibly.


In this document there was no longer dancing around the edges or causing the reader's eyes to glaze over with absurd fairy tales of patients and physicians working together for some nebulous common and conservation of commonly owned resources. Now we are told doctors need to conserve medical resources and get over the archaic obligation to the be patient's advocate.

quoting from Table 1 ( pg 74) Principles that Guide the ACP Ethics Manual recommendations

principle description

Beneficence The duty to promote good and act in the best interest of the patient
and the health of society

Non Maleficence The duty to do no harm to patients

Respect for patient The duty to protect and foster a patient's free uncoerced choice
autonomy

Justice The equitable distribution of the life-enhancing opportunities
afforded by health care

Quoting from page 74 of a supplement to the Annals of Internal Medicine, entitled "American college of Physicians Ethics Manual,sixth edition.


Comment: Right at the beginning the ancient bedrock of medical ethics is quietly altered. Now Beneficence is expanded beyond its traditional meaning altered to include "the health of society"
How has the term been used in the past.

Wikipedia states:
The term beneficence refers to actions that promote the well being of others. In the medical context, this means taking actions that serve the best interests of patients. However, uncertainty surrounds the precise definition of which practices do in fact help patients.

James Childress and Tom Beauchamp in Principle of Biomedical Ethics (1978) identify beneficence as one of the core values of health care ethics. Some scholars, such as Edmund Pellegrino, argue that beneficence is the only fundamental principle of medical ethics. They argue that healing should be the sole purpose of medicine, and that endeavors like cosmetic surgery, contraception and euthanasia fall beyond its purview.
.


Considerations of justice must inform the physician's role as citizen and clinical decisions about resource allocation. The principle of distributive justice requires that we seek to equitably distribute the life-enhancing opportunities afforded by health care. How to accomplish this distribution is the focus of intense debate.More than ever,concerns about justice challenge the traditional role of physician as patient advocate.

A box insert is found on page 87 of the manual:

Box 4  "Patients first and stewardship of resources.

The physician's first and primary duty is to the patient.

Physician must base their counsel on the interests of the individual patient, regardless of the insurance or medical delivery setting.

This physician's professional role is to make recommendations on the basis of the best evidence and to pursue options that comport with the patient's unique health needs,values and preferences."

Ed. OK so far no problem but now

"Physicians have a responsibility to practice effective and efficient health care and to use health care resources responsibly.Parsimonious care that utilizes the most efficient means to effectively diagnose a condition and treat a patient respects the need to use resources wisely and to help ensure that resources are equitably available."

In 2002,  a major offensive against the old ethics appeared in the form of the "Charter for the New Professionalism in the New Millennium "Then things are firmed up in the ACP's new ethics manual

June 2012 AMA joins the bandwagon.

Dr.Richard Fogoros said the following: on his blog the Covert Rationing Blog:

To summarize, by the turn of the millennium doctors were being coerced to withhold healthcare from their patients at the bedside, and thus to violate their time-honored primary professional directive. The intent of the 2002 Charter on medical professionalism was to repair the problem (i.e., to cure the “frustration”), not by confronting the forces of evil doing the coercion, but rather, by simply changing medical ethics to make bedside rationing OK. And that’s just what the document did, though only after careful re-editing to make this radical change to medical ethics sound as benign as possible.

Here we had the great non sequitor which was that  physicians are frustrated by many current forces and situations so to relive their angst we propose they not only worry about the welfare  of their individual patients but they also are responsible for everyone's welfare and the conservation of society's resources.

But how to do that-simple- later we are told simply follow the guidelines.

Wednesday, December 27, 2017

You are only as young as your legs

A high school friend once told me that one of his football coaches told him that wind sprints were important and you were only as young as your legs. I think that this is a physiological insight on the same lofty level as Woody Allens' maxim (1).  The time honored wind sprints have apparently morphed into high intensity interval training which is supposed to be good  for things ranging from improving glucose tolerance to improving 02 uptake and exercise tolerance in heart failure with or without reduced ejection fraction.

The stylized story about muscle loss with aging can be told like this:

From age 40 to age 70 there is 8 % per decade decrease in muscle mass and a 10-15 % decrease in muscle strength. Around age 70 the rate of decline for both increases so that there is a 10-15% decrease in muscle mass per decade and a 25 to 40% decrease in strength.

There is a greater loss in the fast twitch or type 2 fibers with some of the  fast twitch fibers being replaced by type 1.This observation helps explain the greater loss in strength relative to muscle size as type 2 fibers are larger and can generate more force and to some degree they are being replaced by smaller less forceful type 1 fibers.

Decreasing levels of exercise for various reasons accompany aging but not  all  muscle loss can  be blamed on decreased activity. There is to varying degrees loss of the anterior horn cells in the spinal cord which seem to target horn cells that serve type 2 fibers. as well as multiple other changes in muscles that seem refractory to continuing exercise.

 So why should we call the numbers stylized? The estimates of percentage per decade losses are of course averages  which are largely derived from longitudinal studies  and individuals have been noted to vary greatly. Further one study showed that various sample sites from the lateral thigh muscle  which investigators prefer for biopsy studies on muscle fiber type often give rather discrepant fiber distribution counts.




1) As you get older everything that  should be soft gets harder and everything that should be hard get softer. We can all think of examples.

Which master should physicians serve-Dr.Martin Samuels' thoughts

I have written before about what I believe the wrong headed and dangerous views expressed in the Physician Charter.See here.

http://mdredux.blogspot.com/2016/07/is-new-professionalism-and-acps-new.html

Dr.Martin Samuels ,Harvard neurologist, master teacher and lecturer,  expresses his views regarding the issue of who does the physician serve. Which master? See here.

Is the patient or "society" the master? Dr Michel Accad dissects  the related dangerous  notion of population medicine here.


h/t Notes from Dr. RW blog  See here.

Tuesday, December 26, 2017

Inadequate warfarin dosing may be worse than no warfarin in regard to stroke severity

Sokomoto et al (1) investigated the relationship between adequacy of warfarin dosing and severity of stroke in patients with atrial fibrillation. Inadequate was defined as INR less than 2.0 ( less than 1.6 for patients older than 70 years.)

They studied 477 patients with atrial fibrillation (AF) and acute ischemic stroke,53 of whom were undertreated. Inadequate or insufficient dose of warfarin was present in 53 patients and the odds ratio for a severe stroke was 2.7. The numbers in the study were fairly small but  other research had demonstrated a similar pattern.

The authors suggested that underlying pathophysiology or pharmacologic explanation related to the vitamin K dependent anticoagulant protein,Protein C. Protein C levels decrease earlier and with lower doses of warfarin than do the other vitamin K dependent clotting proteins. So early on in warfarin therapy there may be a procoagulant effect. This was why  in the not-too-long ago-days physicians would treat thromboembolism with a few days of heparin along with the warfarin. Too little warfarin may be more of a pro than an anticoagulant medication.

So we have still another reason why the newer oral  direct acting anticoagulants are better than warfarin.




1) Sakamoto, Y et al, Insufficient warfarin therapy is associated with higher severity of stroke than non anticoagulation in patients with atrial fibrillation and acute anterior-circulation Stroke

Circulation Journal Official Journal of the Japanese Circulation society. 2017 December.

Friday, December 22, 2017

All Left bundle Branch Blocks are not the same

The vast majority of patients with an EKG pattern of LBBB have structural heart disease,that is myocardial disease as opposed to disease only involving the conduction system which  is found in a very small minority-usually estimated to be about 1 % of LBBB cases.

It has been  recognized that some patients with isolated or lone LBBB will over a variable period of time develop a cardiomyopathy.The few clinical reports of  this condition suggests delays of up to over twenty years and often dramatic resolution of heart failure with cardiac resynchronization therapy. ( ref 2)

LBBB is associated with  inter-ventricular and intra-ventricular loss of synchrony, the later being more deleterious to cardiac function. Normally the various areas of segments of the left ventricle contract in sync. In LBBB the typically described or stylized  pattern of abnormal septal motion is : there is early contraction of the septal wall with concomitant bulging of the lateral left ventricular wall followed by late contraction of the lateral wall and bulging of the septum.The delayed ventricular contraction is followed by delayed relaxation of the left ventricle.


Han et al  ( ref 1) using tagged cine cardiac MR described 2 different patterns of abnormal septal movement in patients with LBBB.Interestingly in 2 of the  10 patients there was no septal dyskinesia at all. In some cases ( 50%) of LBBB there was dyskinesia of the entire septum while in others only the anterior septum was dyskinetic.This may at least partially explain why some patients with LLLB have little if any exercise intolerance over many years while other notice a decrease in exercise capacity soon after the onset of LBBB as was the situation in my own case and two others with whom I have had blog level correspondence.


Also animal experiments inducing LBBB have shown a rapid and often significant decrease in left ventricular function soon after the onset of LBBB.Perhaps the key is the presence or absence of the normal left to right activation of the interventricular septum and the degree to which conduction across the septum is delayed.The abnormal septal movement is the basis for the echocardiographic finding of "septal flash"

Of course the real game changer element of LBBB story is the capability of His Bundle pacing to "fix" LBBB  , at least in a significant number of patients with LBBB.


1) Han Y et al Circumferential myocardial strain in cardiomyopathy with and without Left bundle branch block. J. of cardiovascular magnetic resonance .Jan 5 2010, doi:101186/1532-42.9x-12.7
full text available on line.

2) Vaillent C et al  Resolution of left bundle branch block induced cardiomyopathy by cardiac resynchronization therapy. J Am College Cardiology 2013 vol 61 1089

Monday, November 27, 2017

How often does the Evidence in EBM turn on statistical subtleties?

A few years ago I posted a piece about the effects of antioxidants on GI tract cancers.There was a reported small increase in Relative Risk (1.06) if one used a fixed effects statistical model but no increase if one used a random effects statistical model analysis.

Here the truth seemed to turn on the choice of statistical method used. How robust could the truth be when it depends on choices made by statisticians and importantly when experts disagree on the choice which was the case quoted above? For a critical reader to decide for himself in a rational way it seems he would have to be fairly conversant in the vagaries of regression analysis and analysis of variance which are the areas where these two competing statistical models live.

I have read that the fixed effect model in general is the one more commonly used and it is the one with lower standard errors and hence more power. I have read that in regard to meta-analysis the fixed effect model is appropriate when the data appear homogeneous and the random effects model when the data are heterogeneous. Then we run up against tests for heterogeneity in regard to which no one should be surprise if statisticians may differ as to the correct way to do that. It seems to me if I writing a paper and wanted it published and since positive studies are more likely to see the light of day in print I would want to use the more powerful fixed effects model.


It seems the deeper you plunge into the analysis of the data the less certain you may become regarding the robustness of the conclusion.But truth does not really turn on the basis of the choice of statistical technique for one meta-analysis.The results of any one study-even if that study is a meta-analysis-should not decide the issue.Prior context and biological plausibility must be taken into account.

Saturday, November 25, 2017

How to survive under socialized medicine

Here is a quote which to me seems may have high titer of deep insight.(my bolding)

"In many areas of medicine, particularly those related to especially politicized areas like CVD and other "life-style" diseases, government-franchised practitioners are often dangerously ignorant of essential facts.
Remember that the worst aspect of socialist medicine is that medicine as a rational science is epistemologically destroyed by eliminating the role of the doctor as a sovereign, independently thinking, professional. "

H/T to Dr. Paul Hsieh in his blog "We Stand Firm" who in turn found it in essay entitled "How to Survive under Socialized Medicine" which was re-published in another blog (ReasonPharm) which in turn credited it to a facebook entry by some one named Christian W. (Please excuse the rather lengthy attribution but I did not want to slight the person who seems to be the actual author.)

. .

Friday, November 17, 2017

The division of internist into hospitalist and "officist" and its demise.

It is the 20th  anniversary of the birth of the hospitalist.A recent article describes what was presented as a fairly widespread feeling among hospitalists  of "not getting no respect. ".

Some of the doctors interviewed  spoke of the hospitalist being a gopher for various attending physicians,a clerk and paper work finisher for numerous physicians and thought of more or less as a intern or junior resident and one who often seemed not worthy of a return phone call.The duties of the hospitalist when I was briefly  in the hospital last year with a pulmonary embolus seemed to fit that pattern. A very pleasant young physician mainly ushered the consulting cardiologist and pulmonary doc in and wrapped up the paper work as both of the consultants made the real decisions regarding testing and treatment. A colleague of mine who attended at that hospital said he made the decisions regarding patients he admitted while the hospitalist was useful in relieving him of paperwork. I realize that the above description does not apply to the situation of all hospitalists.

While the officist has become barely distinguishable from the FP or GP or even NP, the hospitalist , at least in some settings seems to have devolved into a junior  house officer while the real management of the critically ill fall to the cardiologist, the pulmonologist and the intensivist.


In the 1970s and 80s in our internal medicine  practice it was routine for GPs ( they were not FPs at the time) to  refer complicated,sick patients to our groups. ( It seemed to more often than not happen late on Friday afternoons. The physician to whom the referral was made would personally  care for the patient in the hospital  often aided by his  internist specialists partners.)

The sequence was that the patient or referring physician would call the physician in our group -if he was not on call one of the partners would  admit the patient to the hospital and attend to him calling on other partner subspecialists as the situation warranted. Now the patient calls ,for example after hours and the recorded message advises the patient to go to the ER. He is seen by the ER doctor who may admit the patient and the hospitalist would see the patient and consult as needed various specialists. The internist, assuming the patient had one, would often learn of the event when the patient was discharged back to the internist who had nothing to do with his treatment and may or may not have received a copy of the discharge summary.

In describing that archaic situation to young house staff  I would feel like describing the quaint rotary phone that I used when growing up in the 50s.

.  

Monday, November 13, 2017

James Gailbraith combines a belief in perpetual motion machine with believe in there IS a free lunch in his economic advice

Dr. James Galbraith is the son of John Kenneth Galbraith and here the apple falls very close to the tree. See here for his  thoughts published in the Nation. Here is discussion of those comments as formulated by Dr.Paul Hsieh and published on line at Pajamamedia.com blog.

Here are the major points as Dr. Hsieh summarizes them:
  1. The political push to reduce government deficits is economically misguided, based on an irrational “phobia” of deficits.
  2. If we want economic growth, we need more spending. Only banks and governments can stimulate spending because (in his words): “Governments and banks are the two entities with the power to create something from nothing.”
  3. We shouldn’t worry about the alleged impending bankruptcy of Social Security or Medicare — or of the U.S. government itself. Why? Because the government is the source of money and therefore can’t run out.
  4. Government debt is not really a “burden on future generations,” because it never has to be repaid. Each generation can just pass that debt onto the next generation, so there’s no problem.

Think about what he said. Governments and banks can create something from nothing. Yes, I know that the government can "print money" and that banks create money in the fractional reserve banking system but you can't fool all of the people all of the time. The government and banks in Greece seem to have not understood that universal principle as they have made nothing out of something as they made tried to make something out of nothing Apparently the government in Greece has not consulted with Dr. Galbraith as they seemingly have run out of money. His perpetual motion money making machine is that you just keep rolling over debt which was the something that governments made out of nothing and there is no problem. So why did the Germans and the EU have to bail out Greece? Why could not the government just continued to make something from nothing?Why did we see hyper-inflation in Germany? Why are Not all countries made prosperous by this simple technique print more money and spend it.


Wednesday, November 08, 2017

Before Obamacare it was other people's money effect -Afterwards more so



 When something is being payed for with other people's money, more will purchased. This is also true if you merely think someone else is paying for it, as in the situation that exists with employer paid health care insurance.

Quoting myself from 2006:

Medical care came to be "managed " by the managed care sector because of the concept of "other people's money". To a large degree individuals pay for only a portion of their health care the remainder paid by either employers or the government. There was not much fuss made by these other people until the costs of health care rose to some threshold above which employers and other third party payers including CMS thought costs were getting out of hand. Then entered cost containment via the various cost savings actions of managed care.

The effect on the traditional fiduciary duties of physicians to patients by the duties of the for-profit corporation vis-a -vis its shareholders is the root cause of many ethical problems generated by managed care. Basically the HMO and third party payers generally strive to make money or save it and they introduce mechanisms to control physician behavior to that end even if that control involves abrogation of the fundamental duty of the doctor to place the patient well being and interests first. The efforts of the third parties in that regard weaken the physician-patient relationship and damage the trust element in the relationship.Ethical cover for this abrogation was provided by the introduction and unfortunate widespread acceptance by medical professionals organizations of the "New Professionalism" which alleged a physician's duty to society to be a good steward of society resources must somehow be balanced against the physician's duty to the patient.

With Obamacare, more people will be trying to spend other people's money.The biggest other people is CMS who along with HHS will have mandates to control costs. Mix in the decreasing number of primary care doctors to the number of patients seeking care with HHS/CMS moving to decrease health care providers reimbursements and you have a situation in which patient need more than ever an advocate. But patient advocacy will be not longer be the prime directive but merely a factor to be weighed against the imperative to be a steward of society's scare medical resource to the extent that physicians actually internalize the bogus arguments of the New Professionalism.